Endodontic-periodontal combined lesion is a clinical dilemma because making a differential diagnosis and deciding a prognosis are difficult.

Methods: Twenty-six cases from 14 articles involving the successful management of endodontic-periodontal lesions with concurrent regenerative procedures were reviewed. This article also presents successful treatment of an endodontic-periodontal combined lesion involving a grade II mesial furcation of a maxillary molar with root canal treatment and multiple regenerative procedures. Results: A treatment algorithm is outlined for the application of the guided tissue regeneration (GTR) in managing endodontic-periodontal combined
lesion.

This treatment algorithm consists of 4 phases:(1) presurgical phase (determining periodontal/regenerative prognosis), (2) endodontic phase, (3) periodontal
surgical phase, and (4) post-GTR re-evaluation protocol.

Conclusions: The proposed 4-phase treatment algorithm might provide a beneficial guideline in managing the endodontic-periodontal combined lesions.

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